tag:blogger.com,1999:blog-5729624855683907084.post2476635218886950452..comments2023-03-09T03:58:43.140-08:00Comments on 40SomethingFitness: Why EVERYBODY Should be Talking About Metabolic SyndromeAnonymoushttp://www.blogger.com/profile/08573508025243868103noreply@blogger.comBlogger6125tag:blogger.com,1999:blog-5729624855683907084.post-53012818740751438392016-08-22T16:31:48.940-07:002016-08-22T16:31:48.940-07:00Angela - thanks for the comments. It's a toug...Angela - thanks for the comments. It's a tough balance to strike. We actually did dig into genetics and epigenetic factors in another article: http://40somethingfitnesstransformation.blogspot.com/2013/08/are-your-genes-making-you-fat.html<br />Would love to hear your comments on that too.Anonymoushttps://www.blogger.com/profile/08573508025243868103noreply@blogger.comtag:blogger.com,1999:blog-5729624855683907084.post-1315681211393917622016-08-22T16:26:02.925-07:002016-08-22T16:26:02.925-07:00While type II diabetes can be genetic, genetics is...While type II diabetes can be genetic, genetics is not a guarantee that you will get diabetes just because you have the genes for it. Epigenetics has a very big role in one actually turning a gene on and coming down with the phenotype "diabetic." What turns the gene on is a multi-faceted response but even as a genetic state, just as the switch can be turned on, so it can be turned off (or at least put into remission) for life. <br /><br />Thus, while I agree that it is a bit over simplified, I think the purpose it met since not everyone is a scientist knowing everything and many people prefer the simplification. In an article like this, the simpler the better to reach broader audience. <br /><br />You did a great job Michael trying to reduce the complexity to kitchen talk language. Anonymoushttps://www.blogger.com/profile/05152971322616461823noreply@blogger.comtag:blogger.com,1999:blog-5729624855683907084.post-89734482615081982742016-08-18T14:04:22.403-07:002016-08-18T14:04:22.403-07:00The article is a little out of date now, and these...The article is a little out of date now, and these statics are tough to nail down because so much of it is undiagnosed. It's way too much. It's epidemic. And it's costing us our health, our wealth, and our ability to enjoy life. Anonymoushttps://www.blogger.com/profile/08573508025243868103noreply@blogger.comtag:blogger.com,1999:blog-5729624855683907084.post-81294099014029017202016-08-18T11:21:14.556-07:002016-08-18T11:21:14.556-07:00Is it really only 25% With the obesity rates what ...Is it really only 25% With the obesity rates what they are and obesity and metabolic syndrome being linked, isn't it more like 60+%Peggy Hollowayhttps://www.blogger.com/profile/15643574910516963191noreply@blogger.comtag:blogger.com,1999:blog-5729624855683907084.post-15621747900150286542013-03-30T06:36:09.981-07:002013-03-30T06:36:09.981-07:00Thanks for the read and the comments. I will conf...Thanks for the read and the comments. I will confess to taking a simplified approach to a complex subject. I try to walk an appropriate line of accuracy and simplicity for readers to take as a baseline and then continue learning for themselves. <br />You are absolutely right that there are underlying factors that ultimately contribute to full blown Type II. If there weren't even more people would develop it. Why some can tolerate a life of carbohydrate abuse without developing full Type II and others are more susceptible it not clearly established, but it's also not much of a surprise. Everybody has varying tolerances for stimuli. However, absent the lifestyle risk behaviors, I believe most medical professionals would support the assertion that people, even those particularly susceptible, would not develop the disease. <br />I didn't mean to give the impression that the liver secreted growth and sex hormones. This is of course not true. I will refine the sentence structure. <br />Again, thanks. Come back and comment often. It's the dialog that really reveals the best of what we can accomplish together.Anonymoushttps://www.blogger.com/profile/08573508025243868103noreply@blogger.comtag:blogger.com,1999:blog-5729624855683907084.post-63990291403303209432013-03-29T22:28:45.365-07:002013-03-29T22:28:45.365-07:00I noticed that you called Type II Diabetes "c...I noticed that you called Type II Diabetes "completely lifestyle induced." This is false: <br /><br />http://en.wikipedia.org/wiki/Diabetes_mellitus_type_2#Cause<br /><br />There are many genetic and other non-modifiable risk factors. I think it may be more accurate to say that often the *primary* inductive factor appears to be poor nutrition and no exercise leading to obesity/insulin resistance/metabolic syndrome, but this is not true for all, and I suspect in virtually no case is poor nutrition and no exercise *solely* responsible. Diabetes is an extremely complex, multifactorial polygenic disorder with many subtypes that can't be just summed up as "insulin resistance, yo."<br /><br />Insulin resistance, by the way, is also considerably more complicated that just "too much sugar does it."<br /><br />http://en.wikipedia.org/wiki/Insulin_resistance#Causes<br /><br />Also, I'm somewhat confused by your suggestion that the liver is in charge of signaling for secretion of adrenaline, GH, and sex hormones. I'm not aware of any physiologic basis for that, most coordination of those hormones is CNS-based to my knowledge. The liver does participate in GH effects by producing IGF-1, though.<br /><br />All that said, I do think the general advice you give here regarding lifestyle modifications to fight insulin resistance is good. It's pretty much all you can do, given that the other factors are "non-modifiable", and we should all be doing it for lots of other reasons anyway, diabetes or no. I personally think that maintaining or attaining normal weight is probably more important for fighting insulin resistance than reducing "refined" carbs, but we agree on exercise 100%.Anonymousnoreply@blogger.com